干细胞研究院

About Institute

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姓名:孙春辉

学位:博士

科研方向:

干细胞分化、细胞老化与干预

主持/参与项目:

1.国家自然科学基金青年科学基金(31201039)紫薯花青素调控内皮细胞老化的分子机制研究,2013/01-2015/12,主持

2.江苏省自然科学基金青年科学基金(2012143)D609诱导骨髓间充质干细胞神经分化的分子机制研究,2012/07-2015/07,主持

3.徐州市推动科技创新专项资金项目(高校基础研究项目)(KC16SG272)紫甘薯花青素靶向自噬调节间充质干细胞神经分化的机制研究,2016/10-2018/09,主持

4.江苏师范大学博士科研启动项目(11XLR21)类黄酮诱导骨髓来源的间充质干细胞神经分化的分子机制研究,2012/01-2013/12,主持

5.国家自然科学基金青年科学基金(31500766)钛材纳米界面原位调控骨髓间充质干细胞分化的分子机制研究,2016/01-2018/12,参与

6.国家自然科学基金青年科学基金(31501087)依赖于微管解聚驱动蛋白Crkin13和胞质微管解聚的纤毛组装分子机制研究,2016/01-2018/12,参与

7.国家自然科学基金青年科学基金(81400902)TRPV4介导软骨藻酸处理致小鼠认知缺陷的分子机制,2015/01-2017/12,参与

8.国家自然科学基金青年科学基金(31301585)紫苏醛对食品储藏中黄曲霉的抑制作用及机理研究,2014/01-2016/12,参与

代表论文:

1.Chunhui Sun, Hebao Yuan, Li Wang, Xiaoxi Wei, Linford Williams, Paul H Krebsbach, JunLin Guan, and Fei Liu. FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling. Journal of Bone and Mineral Research. 2016 Dec;31(12):2227-2238.

2. Chunhui Sun, Xin Wang, Guihong Zheng, Shaohua Fan, Jun Lu, Zifeng Zhang, Dongmei Wu, Qun Shan, Bin Hu, Yuanlin Zheng. Protective effect of different flavonoids against endothelial senescence via NLRP3 inflammasome. Journal of Functional Foods 2016, 26: 598–609.

3. Chunhui Sun, Shaohua Fan, Xin Wang, Jun Lu, Zifeng Zhang, Dongmei Wu, Qun Shan, Yuanlin Zheng. Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome. J Nutr Biochem. 2015, 26(10):1029-40.

4.Chunhui Sun, Jing Shao, Le Su, Jing Zhao, Jianzhong Bi, Shaonan Yang, Shangli Zhang, Jiangang Gao, Junying Miao*. Cholinergic neuron-like cells derived from bone marrow stromal cells induced by tricyclodecane-9-yl-xanthogenate promote functional recovery and neural protection after spinal cord injury. Cell Transplantation, 2013, 22(6):961-75.

5. Jing Shao,Chunhui Sun, Le Su, Jing Zhao, Shangli Zhang, Junying Miao*. Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells. The international journal of biochemistry & cell biology, 2012, 44(12):2253-2260. (并列第一作者)

6.Chunhui Sun, Xia Liu, Lei Qi, Jiping Xu, Jing Zhao, Yun Zhang, Shangli Zhang, Junying Miao*. Modulation of vascular endothelial cell senescence by integrin β4. Journal of Cellular Physiology, 2011, 225(3):673-681.

7.Chunhui Sun, Nan Wang, Jie Huang, Jie Xin, Fen Peng, Yinshi Ren, Shangli Zhang, Junying Miao*. Inhibition of phosphatidylcholine-specific phospholipase C prevents bone marrow stromal cell senescence in vitro. Journal of cellular biochemistry, 2009, 108(2):519-28.

8. Nan Wang,Chunhui Sun, Siwei Huo, Yun Zhang, Jing Zhao, Shangli Zhang, Junying Miao*. Cooperation of phosphatidylcholine-specific phospholipase C and basic fibroblast growth factor in the neural differentiation of mesenchymal stem cells in vitro. The international journal of biochemistry & cell biology, 2008, 40(2):294-306. (并列第一作者)

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