干细胞研究院

About Institute

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姓名:葛慎光

学位:博士

科研方向:

1. 功能纳米材料制备、纳米与生物分子的相互作用

2.生物传感器的构建及应用、传感器信号转换与放大新原理和新方法

3.微流控纸芯片性能调控和传感机制研究、器件的开发和研制

4.电化学分析、光致电化学分析、比色分析、荧光分析及荧光成像

主持项目:

1.国家自然科学基金面上项目-纸芯片甄别检测高侵袭恶性循环肿瘤细胞的新方法-(21775055)

2.国家自然科学基金面上项目-基于中空通道纸芯片的自推进分离捕获循环肿瘤细胞及原位分析-(No.21575051)

3.国家自然科学基金青年基金-基于点击化学的微囊藻毒素化学传感器构建-(No.21207048)

4.山东省自然科学基金-功能化石墨烯电化学传感器的构建及其在免疫学中应用-(No.ZR2011BQ019)

5.山东省自然科学基金/省属高校优秀青年基金-多功能纸芯片分离捕获外周血中肿瘤细胞及原位分析-(No.ZR2015JL006)

6.山东省科技发展计划-研制纸芯片器件对水体中农药残留的检测与监控-(No. 2014GGX103012)

7.济南市青年科技明星计划-含反应基团的Si/C/N陶瓷前驱体聚硅氮烷的制备及性能研究-(No.20110102)

8.中国科学院环境化学与生态毒理学国家重点实验室开放基金-基于纸微芯片的电化学发光免疫分析研究-(No.KF2011-03)

9.济南大学博士基金-纸微芯片上电致化学发光行为研究-(No.XBS1428)

授权发明专利:

1.检测痕量农药残留物的分子印迹化学发光传感器及其应用-(发明专利:ZL200910018139.8)

2.检测痕量农药残留物的电致化学发光传感器的制备及应用-(发明专利:ZL 201010507594.7)

3.水泥材料自修复的分子自组装微球制备及应用-(发明专利:ZL201010524199.X)

4.一种基于点击化学仿生分子印迹电化学传感器的制备及对食品过敏原的检测-(发明专利:201210472177.2)

5.用于叶酸过表达癌细胞快速检测的比色方法-(发明专利:201410124906.4)

6.一种电聚合分子印迹聚合物中空通道纸器件的制备及在农药残留即时检测中的应用-(发明专利:201410436014.8)

科技奖励

1.基于结构调控和光电性能的纸芯片微流控基础研究与传感机制,山东省自然科学奖一等奖。

2.纸芯片传感器纳米材料构建传感界面和实现信号放大,山东省高等学校优秀科研成果奖一等奖。

3.基于新型发光试剂和传感器设计的高选择性发光分析研究,山东省高等学校优秀科研成果奖一等奖。

4.纸芯片传感器纳米材料构建传感界面和实现信号放大,济南大学优秀科研成果一等奖。

5.新型荧光试剂的合成及在分析中应用,济南大学优秀科研成果二等奖。

6.新型荧光探针的设计及在环境检测中的研究,济南大学优秀科研成果三等奖。

7.含共轭结构的有机硅聚合物的制备及应用,山东省科技进步奖 三等奖。

8.新型多功能聚硅氮烷的开发及应用研究,中国石油和化学工业联合会 三等奖。

9.新型含氮聚硅烷的制备与应用,中国建筑材料联合会 科技进步二等奖。

10.微流控纸芯片的功能调控技术及其应用,中国石油与化学工业联合会 二等奖。

代表论文:

1 Linlin Liang, Feifei Lan,Shenguang Ge*, Jinghua Yu, Na Ren, and Mei Yan, Metal-Enhanced Ratiometric Fluorescence/Naked Eye Bimodal Biosensor for Lead Ions Analysis with Bifunctional Nanocomposite Probes, Analytcial Chemistry, 2017, 89, 3597−3605.

2Shenguang Ge,† Lina Zhang,† Yan Zhang, Feifei Lan, Mei Yan, Jinghua Yu*,Nanomaterials Modified Cellulose Paper as a Platform for Biosensing Application, nanoscale, 2017, 9, 4366-4382

3Shenguang Ge†, Feifei Lan†, Linlin Liang, Na Ren, Li Li, Haiyun Liu, Mei Yan, Jinghua Yu*, Ultrasensitive Photoelectrochemical Biosensing of Cell Surface N-glycan Expression Based on the Enhancement of Nanogold-assembled Mesoporous Silica Amplified by Graphene Quantum Dots and hybridization Chain Reaction, ACS Applied Materials & Interfaces, 2017,9(8), 6670-6678.

4 Xiaolu Sun, Chaomin Gao, Lina Zhang, Mei Yan, Jinghua Yu,Shenguang Ge*,Photoelectrochemical sensor based on molecularly imprinted film modified hierarchical branched titanium dioxide nanorods forchlorpyrifos detection,Sensors & Actuators: B. Chemical,2017,251, 1-8.

5.Linlin Liang, Feifei Lan, Xuemei Yin,Shenguang Ge*, Jinghua Yu, Mei Yan, Metal-Enhanced Fluorescence/Visual Bimodal Platform forMultiplexed Ultrasensitive Detection of MicroRNA with Reusable Paper Analytical Devices, Biosensors and Bioelectronics, 2017, 95, 181–188

6 Feifei Lan, Guoqiang Sun, Linlin Liang,Shenguang Ge*, MeiYan, JinghuaYu, Microfluidic paper-based analytical device for photoelectrochemical immunoassay with multiplex signal amplification using multibranched hybridization chain reaction and PdAu enzyme mimetics, Biosensors and Bioelectronics, 2016, 79, 416–422.

7Shenguang Ge, Kaiqing Wu, Yan Zhang, Mei Yan, Jinghua Yu*, Paper-based biosensor relying on flower-like reduced graphene guided enzymatically deposition of polyaniline for Pb2+detection, Biosensors and Bioelectronics, 2016, 80, 215-221.

8 Linlin Liang, Min Su, Li Li, Feifei Lan, Guangxin Yang,Shenguang Ge*, Jinghua Yu, Xianrang Song, Aptamer-based fluorescent and visual biosensor for multiplexed monitoring of cancer cells in microfluidic paper-based analytical devices, Sensors & Actuators: B. Chemical, 2016, 229,347-354.

9 Haiyun Liu, Lina Zhang, Meng Li, Mei Yan, Mei Xue, Yan Zhang, Min Su, Jinghua Yu,Shenguang Ge*,Electrochemiluminescence-molecular logic gates based on MCNTs for the multiplexed analysis of mercury (II) and silver (I) ions,RSC Advances, 2016, 6, 26147 – 26154

10 Linlin Liang, Feifei Lan, Li Li, Min Su,Shenguang Ge*, Jinghua Yu, Haiyun Liu, Mei Yan, Fluorescence “turn-on” determination of H2O2 using multilayer porous SiO2/NGQDs and PdAu mimetics enzymatic/oxidative cleavage of single-stranded DNA, Biosensors and Bioelectronics, 2016, 82, 204–211.

11Shenguang Ge, Linlin Liang, Feifei Lan, Yan Zhang, Yanhu Wang, Mei Yan, Jinghua Yu*, Photoelectrochemical Immunoassay Based on Chemiluminescence as Internal Excited Light Source, Sensors and Actuators: B,2016, 234, 324-331.

12 Linlin Liang, Feifei Lan, Li Li,Shenguang Ge*, Jinghua Yu, Na Ren, Haiyun Liu, Mei Yan, Paper Analytical Devices for Dynamic Evaluation of Cell Surface N-Glycan Expression via a Bimodal Biosensor Based on Multibranched Hybridization Chain Reaction Amplification, Biosensors and Bioelectronics, 2016, 86: 756-763.

13Shenguang Ge, Feifei Lan, Feng Yu, Jinghua Yu*, Applications of Graphene and Related Nanomaterials in Analytical Chemistry, New Journal of Chemistry, 2015, 39, 2380--2395.

14Shenguang Ge, Lina Zhang, Jinghua Yu*, Paper-based microfluidic devices in bioanalysis:how far have we come?, Bioanalysis, 2015, 7(6), 633-636.

15Shenguang Ge, Weiping Li, Mei Yan, Xianrang Song and Jinghua Yu, Photoelectrochemical Detection of Tumor Marker Based on CdS Quantum Dots/ZnO Nanorods/Au@Pt-Paper Electrode 3D Origami Immunodevice, Journal of Materials Chemistry B, 2015, 3, 2426–2432.

16Shenguang Ge, Yan Zhang, Lina Zhang, Linlin Liang, Mei Yan, Jiadong Huang, Jinghua Yu,* and Mingwei Sun,Ultrasensitive Electrochemical Determination of Cancer Cells Based on TrimetallicDendritic Au@PtPd Nanoparticles for Signal Amplification on Lab-on-Paper Device,Sensors and Actuators: B,2015, 220, 665-672.

17 Long Li, Lina Zhang, Jinghua Yu,Shenguang Ge*, Xianrang Song*,All-Graphene Composite Materials for Signal Amplification toward Ultrasensitive Electrochemical Immunosensing of Tumor Marker, Biosensors and Bioelectronics, 2015, 71, 108-114.

18Shenguang Ge, Yan Zhang, Lina Zhang, Haiyun Liu, Jiadong Huang, Mei Yan, Jinghua Yu,*Electrochemical K-562 Cells Sensor Based on Origami Paper Device for Point-of-care Testing, Talanta, 2015,145,12-19.

19 Lei Ge, Min Su, Xutang Tao*,Shenguang Ge*, Application of Au cage/Ru(bpy)32+ nanostructures for the electrochemiluminescence detection of K562 cancer cells based on aptamer, Sensors and Actuators: B. 2015, 214, 144–151 .

20 Shenguang Ge, Weiyan Liu, Haiyun Liu, Fang Liu, Jinghua Yu, Mei Yan*, Jiadong Huang*,Colorimetric detection of the flux of hydrogen peroxide released from living cells based on the high peroxidase-like catalytic performance of porous PtPd nanorods, Biosensors and Bioelectronics, 2015, 71, 456-462.

21 Guoqiang Sun, Hongmei Yang, Yan Zhang, Jinghua Yu,Shenguang Ge*, Mei Yan, Xianrang Song, Branched zinc oxide nanorods arrays modified paper electrode for electrochemical immunosensing by combining biocatalytic precipitation reaction and competitive immunoassay mode, Biosensors and Bioelectronics, 2015, 74, 823–829.

22Shenguang Ge, Fang Liu, Weiyan Liu, Mei Yan, Xianrang Song and Jinghua Yu,Colorimetric assay of K-562 cells based on folic acid-conjugated porous bimetallic Pd@Au nanoparticles for point-of-care testing,Chem. Commun., 2014, 50, 475-477.

23Shenguang Ge, Mingwei Sun, Weiyan Liu, Shuai Li, Xiu Wang, Chengchao Chu, Mei Yan, Jinghua Yu, Disposable electrochemical immunosensor based on peroxidase-like magnetic silica–graphene oxide composites for detection of cancer antigen 153, Sensors and Actuators B, 2014, 192, 317–326.

24Shenguang Ge, Lei Ge, Mei Yan, Xianrang Song, Jinghua Yu, Shanshan Liu, A disposable immunosensor device for point-of-care test of tumor marker based on copper-mediated amplification,Biosensors and Bioelectronics,2013, 43, 425-431.

25Shenguang Ge, Weiyan Liu,Lei Ge, Mei Yan, Jixian Yan, Jiadong Huang, Jinghua Yu,In Situ Assembly Porous Au-paper Electrode and Functionalization ofMagnetic Silica Nanoparticles with HRP via Click Chemistry for Microcystin-LR Immunoassay,Biosensors and Bioelectronics, 2013, 49, 111–117.

26Shenguang Ge, Lei Ge, Mei Yan, Xianrang Song, Jinghua Yu* and Jiadong Huang, A Disposable Paper-based Electrochemical Sensor with Addressable Electrode Array for Cancer Screening,Chem. Commun., 2012, 48 (75), 9397 – 9399.

27 Mei Yan#,Shenguang Ge#, Weiqiang Gao, Chengchao Chu, Jinghua Yu, Xianrang Song, Fluorescence Immunosensor Based on p-acid encapsulated Silica Nanoparticles for Tumor Marker Detection, Analyst, 2012, 137 (12), 2834 - 2839.

28Shenguang Ge, Mei Yan, Juanjuan Lu, Meng Zhang, Feng Yu, Jinghua Yu, Xianrang Song, Shilin Yu, Electrochemical Biosensor Based on Graphene Oxide–Au Nanoclusters Composites forL-Cysteine Analysis.Biosensors and Bioelectronics, 2012, 31, 49-54.

29Shenguang Ge, Xiuling Jiao, Dairong Chen,Ultrasensitive Electrochemical Immunosensor for CA 15-3 Using Thionine-Nanoporous Gold-Graphene as Platform and Horseradish Peroxidase-Encapsulated Liposome as Signal Amplification,Analyst, 2012,137, 4440-4447.

30Shenguang Ge, Feng Yu, Lei Ge, Mei Yan, Jinghua Yu, Dairong Chen, Disposable Electrochemical Immunosensor for Simultaneous Assay the Panel of Breast Cancer Tumor Markers, Analyst,2012, 137 (20), 4727 - 4733.

学生科创:

第十五届“挑战杯”·中国银行全国大学生课外学术科技作品竞赛一等奖,指导教师:葛慎光,2017.11

第十五届“挑战杯”·海尔山东省大学生课外学术科技作品竞赛决赛特等奖,指导教师:葛慎光,2017.5

首届山东省大学生科技创新大赛二等奖,指导教师:葛慎光,2014-12-15.

第三届山东省大学生科技创新大赛二等奖,指导教师:葛慎光,2016-12.

国家级大学生创新创业训练计划,指导教师:葛慎光

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